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KMID : 0351819930340030151
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Kyunpook University Medical Journal
1993 Volume.34 No. 3 p.151 ~ p.160
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Transfer of Immunity to Clonorchis sinensis Infection by Peritoneal Cells, Spleen Cells
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Sung Ho KIM
Hyun Hee KONG/Chu Hwan MOON and Dong Wik CHOI
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Abstract
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The effect of peritonal cells (PC) and sera and/or spleen cells (SC) and sera of BALB/c mice on tansfer of immunity against Clonorchis sinensis(C. sinensis) to the syngeneic recipient mice was studied. Group Ⅰ of donor mice were sensitized by injecting the admixture of the metabolic products, and Group Ⅱ by the somatic constituents, of C. sinensis and Freund's incomplete adjuvant into footpads twice at 2 weeks' interval. After challenge infection with metacercariae of C. sinensis, the eggs of control groups appeared earlier and much more numerously than those of recipient groups. There was a significant difference in worm burdens between one of the recipient and control groups. There were a small number of plaque forming cells(PFC) in all sensitized groups, but no PFC in the control mice. It was found that PC and sera of BALB/c mice are able to transfer immunity against C. sinensis to syngeneic recipients.
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